Principles of Biochemistry integrates an introduction to the structure of macromolecules and a biochemical approach to cellular function. Topics addressing protein function will include enzyme kinetics, the characterization of major metabolic pathways and their interconnection into tightly regulated networks, and the manipulation of enzymes and pathways with mutations or drugs. An exploration of simple cells (red blood cells) to more complex tissues (muscle and liver) will be used as a framework to discuss the progression in metabolic complexity. Learners will also develop problem solving and analytical skills that are more generally applicable to the life sciences.
New in version 2, learners will explore how alteration of these metabolic pathways relates to the development and progression of some human diseases.
What you'll learn:
- The structure and function of the chemical building blocks of life
- How to navigate protein structures using PyMOL
- The central role of enzymes in catalyzing the reactions of life
- The primary metabolic pathways that power cells
- The intricate mechanisms that regulate cellular metabolism
- The integration of biochemical processes in the context of cells, tissues, and whole organisms
- How metabolic perturbations are linked to various human diseases
Image credit: PDB ID 2DN1, 2DN2
Park S-Y, Yokoyama T, Shibayama N, Shiro Y, Tame JRH (2006) 1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms. J Mol Biol 360: 690–701.