Big data is everywhere. A fundamental goal across numerous modern businesses and sciences is to be able to utilize as many machines as possible, to consume as much information as possible and as fast as possible. The big challenge is how to turn data into useful knowledge. This is a moving target as both the underlying hardware and our ability to collect data evolve. In this class, we discuss how to design data systems, data structures, and algorithms for key data-driven areas, including relational systems, distributed systems, graph systems, noSQL, newSQL, machine learning, and neural networks. We see how they all rely on the same set of very basic concepts and we learn how to synthesize efficient solutions for any problem across these areas using those basic concepts.