The Smithsonian Institution is the world's largest museum, education, and research complex, with nineteen museums and the National Zoo. It preserves our heritage, discovers new knowledge, and shares our resources with the world. In its new strategic plan, the Smithsonian sets out a bold agenda to serve as a catalyst for the exchange of ideas; to become a force for civic engagement, understanding, tolerance, creativity, and innovation; and to inspire informed and curious learners to explore, think critically about, and help solve the complex global challenges facing our world. Using case studies and program models from the Smithsonian and other museums, we explore, evaluate, and discuss approaches being developed and used to promote civic engagement, convene public dialogue, promote career and leadership development, broaden audiences, and measure impact. Guest lecturers include staff from the Smithsonian and other museums who are leading the development and research of innovative and effective programming.