What you'll learn

  • Organizing high throughput data
  • Multiple comparison problem
  • Family Wide Error Rates
  • False Discovery Rate
  • Error Rate Control procedures
  • Bonferroni Correction
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Course description

In this course, you’ll learn various statistics topics including multiple testing problems, error rates, error rate controlling procedures, false discovery rates, q-values, and exploratory data analysis. We then introduce statistical modeling and how it is applied to high-throughput data. In particular, we will discuss parametric distributions, including binomial, exponential, and gamma, and describe maximum likelihood estimation. We provide several examples of how these concepts are applied in next-generation sequencing and microarray data. Finally, we will discuss hierarchical models and empirical Bayes along with some examples of how these are used in practice. We provide R programming examples in a way that will help make the connection between concepts and implementation.

This class was supported in part by NIH grant R25GM114818.

 

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Instructors

  • Rafael Irizarry

    Professor of Biostatistics, T.H. Chan School of Public Health

  • Michael Love

    Assistant Professor, Departments of Biostatistics and Genetics, UNC Gillings School of Global Public Health

Associated Schools

  • Harvard T.H. Chan School of Public Health

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